Frank Ferry: City pastimes make downtime fun, exciting

The city of Santa Clarita is an active community where residents enjoy and embrace healthful lifestyles. In our city, recreation and team sports programs are more than a pastime for many Santa Clarita families ? they are a way of life.

The Santa Clarita City Council believes quality recreation and solid infrastructure help to build a stronger community. That?s why our city?s Parks, Recreation and Community Services Department maintains one of the largest budgets in the city of Santa Clarita. Quality recreation classes and well maintained parks and facilities play a vital role in enriching the lives of youth and invigorating the community with physical, cultural and educational experiences.

In a typical summer, the city offers more than 1,000 classes. In the last 25 years, more than 1 million people have enjoyed city classes and enrolled in aquatics, youth sports, day camps and other healthful activities.

The following are just a few of the family-friendly programs and amenities available in our community, supporting healthy, connected families now and for generations to come.

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City?s park system

No matter how you look at it, parks bring families together. Parks are the perfect place to refine a baseball swing or learn football, and a great place to unwind after a long day.

Since 1987, Santa Clarita has built, enhanced or incorporated parks across the community, and today maintains a total of 24 parks with 310 acres of parkland and more than 6,100 acres of open space.

The city built the 60-acre, state-of-the-art Santa Clarita Sports Complex, inclusive of the aquatics center, skate park, sand volleyball court, gymnasium and activities center, as well as the 130-acre Central Park with youth and community health in mind.

These facilities offer residents baseball diamonds, playing fields, basketball and racquetball courts, dog parks, an Olympic-sized swimming pool, a 25-meter dive pool and family activity pool with water play equipment and a 168-foot water slide. Programming at these facilities and others across the city is geared to meet the sports and recreational needs of the entire community.

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Recreation all year long

Since the city?s inception, recreation and youth sports attendance and programming has skyrocketed at the city?s parks and recreation facilities. In the last few years alone, enrollment for specialty classes has experienced a 400 percent increase, while the city?s aquatics programs have grown from eight water classes in 1990 to 46 programs in 2012.

Aquatics classes continue to be a favorite among residents, particularly in the summer when temperatures rise. In fact, aquatics classes are so popular that, when registration opened for summer programming May 8, more than 1,000 participants were enrolled in less than a day. Santa Clarita loves to swim as evidenced by usage at the City?s six pools, which consistently experience record-breaking attendance. Last year alone, more than 307,000 people visited city aquatic facilities.

In addition to a variety of popular youth programs, the city also offers recreational opportunities for adults, including soccer, volleyball, basketball and softball.

One of the most popular sports is the adult softball league with more than 200 teams each season and approximately 3,000 adults enjoying weekly games at Santa Clarita parks.

One of the city?s recent recreation efforts is its popular Inclusion Program, which was awarded a $9,500 grant to partner with the National Inclusion Project to implement Let?s ALL Play. The city?s participation in this program allows children with special needs the opportunity to enjoy local recreation programs with children without disabilities.

Since 2008, the program has grown by 600 percent. The Inclusion Program allows the city to provide safe and nurturing experiences for children with special needs, integrating them in traditional programs, such as swimming, arts and crafts, and physical fitness, and providing an improved quality of life.

Creating affordable, quality activities for people of all ages is a top priority for the City Council. That?s why the city?s quarterly Seasons magazine, which is delivered to more than 67,000 households in the city of Santa Clarita, is always filled with free and low-cost recreational, cultural and educational classes.

Whether it?s Hawaiian dancing, sushi making, dog agility classes, basketball or summer day camps, there are hundreds of opportunities to choose from for those interested in trying a new sport, refining a favorite, finding a new hobby or enjoying a favorite Santa Clarita pastime.?

For more information about the city?s recreation programs, contact 661-250-3700 or visit Santa-Clarita.com.

Frank Ferry is a Santa Clarita City Councilman and can be reached at: fferry@santa-clarita.com.

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Essential Information About Sharepoint Search Software

Sharepoint search software is a product by Microsoft that manages and centralizes essential content for the user's benefit. This product is most beneficial to corporation and and companies that are widely known and need exemplary aid in boosting the companies files and data. The product centers around the ability to download, edit, create queries, store, upload, and search for files or individuals to share with other associates or extended groups. The system allows the developer access to three essential tools, which are Microsoft Office Share point, Microsoft Server Finder, and Windows Share point Services.

However, these specific services operate effectively together, each of these services can also function separately because they are each a web-based affiliation programmed to assist. By comprehending the software and its many functions an organization can ameliorate their efficiency in storing information much more effectively. Microsoft themselves has given an adequate clarification and explication about the abundant services they will offer. However, the product this article will focus on and expand on is the Microsoft Server engine.

The method of Microsoft server is based upon composites. Composites are willingly giving tools and applications to be utilized for company issues and solutions. Accelerating many processes is what Share points mission is about, while simultaneously creating solutions to issues using codes that are hands-on and simple. One of the best software's that Microsoft is known for is their Share point Software, which has been upgraded to work more efficient than ever.

This Microsoft Server is also known as an enterprise exploration service. Thus is the creation of content from various sources

that becomes easily accessed by a specific crowd. MOSS has the capability of the Windows Server including the service index and query engine. Having been created on the ASP.NET framework, it may not collaborate well with other server systems.

Another tool that a developer can utilize with the enterprise query is a person finder function that allows any user to search for individuals. The engine will base the findings on expertise or associations. However, it is only allowed if the tool designs provide the information in an accessible manner. If the data has been transferred onto an individuals server user groups will consist of certain directories.

Utilizing this specific service engine assists the user in discovering a wide range of assets, such as searching and creating queries. This tool, also known as FAST search, has been upgraded successfully by Microsoft to work efficiently with other products in the brand. The FAST service tool harbors the ability to process content rapidly through their efficient and refining pipeline. FAST enhances their ability to find individuals and information.

Indexing is a specific program tailored from a similar tool in Windows that uses a term called crawling rules, which indexes data that needs to be saved. The engine also features a UI to maintain management and stability of the engine. Typing errors will not be problematic as it assists the user promptly. Indexing is a major particle in this software.

This server is based upon assisting companies with completing and sharing information with others in a more efficient and effective manner. This system provides an abundance of options to utilize when searching for an individual or file. Managing any corporations data will become instantly easier while using this software. The Microsoft Search Server is a must for poor organizational skills within companies.

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U.S. marks 150th anniversary of Homestead Act offering free land

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Pakistan: Agriculture Activities: 40 candidates in race for Pamco top ...

40 candidates in race for Pamco top slot


Some 40 candidates have submitted applications for the slot of Chief Executive Officer of Punjab Agriculture and Meat Company (PAMCO) after the resignation of its CEO Dr Hamid Jalil around two weeks ago.


Sources said that May 18 was the last date for submission of applications which was expired. The candidates in the race for the PAMCO chief slot include drawn from multinationals, business, agriculture and meat sectors.?


A high powered committee will hold the interviews, while chief minister will himself finalize the name for company chief. The position of CEO had fallen vacant recently after the resignation of its incumbent Dr Hamid Jalil.



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How to stop Twitter from tracking you across the Internet

This week Twitter announced a new version of its "Who to Follow" feature, making it a far more personal recommendation engine. The way it works, however, is that if you're logged into Twitter in the web browser, any site that calls Twitter code -- like a Tweet or Follow button -- can report your presence on that site back to Twitter. Gadget sites. Car sites. Movie sites. Porn sites. Gaming sites. Any. Site. Here's how to turn it off.

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Sean Penn Rips "Whole F***ing World" for Abandoning Haiti

Fun fact: Sean Penn, the man who played stoner Jeff Spicoli in 1982's Fast Times at Ridgemont High, doesn't abide slackers. We know this because the very outspoken activist ripped into the media -- and mankind at large -- at a May 17 press conference to promote a Hiati fundraiser he's throwing at the Cannes Film Festival. Penn's gripe? No one is doing their part to help the small Caribbean republic, which has recently been devestated by earthquakes, flooding and cholera.

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Octashop ? the complete platform for ecommerce - Online-business ...

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Thus, Octashop offers a complete ecommerce platform for those who want to set up their own business. It helps in creating whole new opportunities for its clients so as to make global success for ecommerce. No doubt, with the help of this company, you can make your online business famous all across the world.

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SEO Services ? Excellent Platform for Progress of Traffic

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Researchers reveal an RNA modification influences thousands of genes

Friday, May 18, 2012

Over the past decade, research in the field of epigenetics has revealed that chemically modified bases are abundant components of the human genome and has forced us to abandon the notion we've had since high school genetics that DNA consists of only four bases.

Now, researchers at Weill Cornell Medical College have made a discovery that once again forces us to rewrite our textbooks. This time, however, the findings pertain to RNA, which like DNA carries information about our genes and how they are expressed. The researchers have identified a novel base modification in RNA which they say will revolutionize our understanding of gene expression.

Their report, published May 17 in the journal Cell, shows that messenger RNA (mRNA), long thought to be a simple blueprint for protein production, is often chemically modified by addition of a methyl group to one of its bases, adenine. Although mRNA was thought to contain only four nucleobases, their discovery shows that a fifth base, N6-methyladenosine (m6A), pervades the transcriptome. The researchers found that up to 20 percent of human mRNA is routinely methylated. Over 5,000 different mRNA molecules contain m6A, which means that this modification is likely to have widespread effects on how genes are expressed.

"This finding rewrites fundamental concepts of the composition of mRNA because, for 50 years, no one thought mRNA contained internal modifications that control function," says the study's senior investigator, Dr. Samie R. Jaffrey, an associate professor of pharmacology at Weill Cornell Medical College.

"We know that DNA and proteins are routinely modified by chemical switches that have profound effects on their function in both health and disease. But biologists believed mRNA was simply an intermediate between DNA and protein," he says. "Now we know mRNA is much more complex, and defects in RNA methylation can lead to disease."

Indeed, as part of the study, the researchers demonstrated that the obesity risk gene, FTO (fat mass and obesity-associated), encodes an enzyme capable of reversing this modification, converting m6A residues in mRNA back to regular adenosine. Humans with FTO mutations have an overactive FTO enzyme, which results in low levels of m6A and causes abnormalities in food intake and metabolism that lead to obesity.

The researchers uncovered links between m6A and other diseases as well.

"We found that m6A is present in many mRNAs encoded by genes linked to human diseases, including cancer as well as several brain disorders, such as autism, Alzheimer's disease, and schizophrenia," says the study's lead investigator, Dr. Kate Meyer, a postdoctoral researcher in Dr. Jaffrey's laboratory.

"Methylation in RNA is a reversible modification that appears to be a central step in a wide variety of biological pathways and physiological processes," she says.

The first time that m6A was detected in mRNA was in 1975, but at the time scientists were unsure whether this finding was a result of contamination by other RNA molecules, Dr. Jaffrey says. Over 90 percent of RNA is either transfer RNA (tRNA) or ribosomal RNA (rRNA), cellular workhorses that are routinely modified.

But Dr. Jaffrey says he has always been interested in the idea that mRNA may be modified -- "DNA, proteins, other forms of RNA are modified, so why not mRNA?" he says -- so he and investigators in his laboratory developed a technique to help them uncover methylation in mRNA taken from both mouse and human samples.

They used two different antibodies that recognize and bind to m6A in mRNA in order to selectively isolate the mRNAs that contain m6A. By subjecting these mRNAs to next-generation sequencing, they were able to identify the sequence of each individual mRNA they had isolated. Co-authors Dr. Christopher Mason and Dr. Olivier Elemento, assistant professors from the Department of Physiology and Biophysics and Computational Genomics in Computational Biomedicine at Weill Cornell Medical College, then developed computational algorithms to reveal the identity of each of these methylated mRNAs.

The Weill Cornell researchers don't know how the thousands of m6As they detected in humans work to control the function of mRNAs, but they do note that the m6As are located near "stop codons" in mRNA sequences. These areas signal the end of translation of the mRNA, suggesting that m6A might influence ribosomal function. "But we really don't know yet," says Dr. Mason, a co-lead investigator on the study. "It may allow other proteins to bind to mRNA, or subject these mRNAs to a whole new regulatory pathway. Our bioinformatics analyses are providing several hints about the possible impact of methylation on RNA function."

Indeed, in their study, the investigators have already found that m6A sites frequently occur in regions of mRNA that are highly conserved across several species of vertebrates. "This shows that m6A sites are not just important for humans, but rather are maintained under selection across hundreds of millions of years of evolution, and thus are likely of critical importance for all animals," Dr. Mason says.

"This is the first demonstration of an epitranscriptomic modification -- alterations in RNA function that are not due to changes in the underlying sequence," he adds.

"These findings are very, very exciting, and amazing, really, when you consider that mRNA has been around for so long and that nobody realized, in all this time, that they were being regulated in this way," Dr. Jaffrey says. "It was right under our noses."

In addition to investigating how m6A regulates mRNAs within cells, the researchers are now focused on identifying the enzymes and pathways that control mRNA methylation.

Their study already demonstrates that FTO is capable of reversing adenosine methylation and suggests that it acts on a large proportion of cellular mRNA. "FTO mutations are estimated to occur in one billion people worldwide and are a leading cause of obesity and type 2 diabetes. Our studies link m6A levels in mRNA to these major health problems and identify for the first time the mRNAs which are potentially targeted by FTO," Dr. Meyer says.

The investigators are currently working to understand how defective regulation of m6A in patients with FTO mutations causes obesity and metabolic disorders, and they are also developing tests to rapidly identify compounds that inhibit FTO activity. These compounds are expected to inhibit the overactive FTO found in humans, potentially leading to novel therapeutics for diabetes and obesity.

Other study co-authors are Yogesh Saletore and Paul Zumbo, members of Dr. Mason's Integrative Functional Genomics laboratory, in the Department of Physiology and Biophysics at Weill Cornell.

Weill Cornell Medical College has filed a provisional patent on the techniques used to detect m6A. The study was funded by National Institutes of Health grants and the Starr Cancer Consortium.

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New York- Presbyterian Hospital/Weill Cornell Medical Center/Weill Cornell Medical College: http://www.med.cornell.edu

Thanks to New York- Presbyterian Hospital/Weill Cornell Medical Center/Weill Cornell Medical College for this article.

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