Mobile Finance gets smarter, faster, better | Calgary Debt ...


We first announced Google Finance for smartphones in August, bringing your latest portfolio quotes and market charts to your fingertips, even when you?re away from your desk. But what about mutual funds and portfolios? Today we?re pleased to announce a number of improvements to the mobile site that will make it easier ? and faster ? to get your key finance updates on the go.

Mutual Funds
Now in addition to seeing the latest stock and market index quotes on the mobile site, you can view mutual funds? prices, performance and key statistics on your smartphone just by entering the ticker into the search box.


Finance Blog

Source: http://finance101now.com/2011/10/mobile-finance-gets-smarter-faster-better/

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Holiday Cars Which Will Prove Lowest Prices! | AutoRoll - Travel ...

My guidance to travelers to a foreign nations is certainly not, ?don?t leave home without it? but alternatively ?Do not take anything for granted.? A car hire Italy, or where ever, as an example, is an excellent way to experience your vacation. Your itinerary is your own and most flexible for your pleasure packed benefit!

Wish to stop in Asiago for a sampling of some well known cheese? Or, just maybe a drive up the amazing Amalfi coast? Perhaps one or two days on the Italian Riviera is just what the doctor ordered. What ever your interests, a holiday automobile hire makes it all fall into place, reserve yours early!

Nobody else is running your schedule. None of this hopping in and out of tour buses, looking as touristy as you possibly can, and watching Vita La Italiana from behind the sun screened windows of your speeding tour coach. Forget intimate shopping at the quaint street market, or trying to find that antique treasure in a little out of the way shop. No, without the liberty of your own rental automobile you?ll be limited to the tourist traps with the hoard of other tour bus passengers.

The choices you make at this present point may be of more strategic importance than you might think initially. Holiday cars is one such call. After all , Milan, the center of Italy?s fashion industry, is coming up on your itinerary and you don?t need to strain your shopping budget solely for a car hire you really can certainly not afford.

In fact your more critical selections begin well before your option of which auto. What car rental company will you select for your holiday vehicle? Will they provide a good tourist support capability, or is it bare bones and good luck the instant you pull out of their parking lot? How many locations are available? The more the better. Do they understand your local tongue? Do they supply free all inclusive quotes for their holiday cars?

You need a sophisticated world wide holiday cars
network that not only gets you the lowest provable price but off and running on your journey as well! Book in advance online using the company that is suitably big and cares enough to provide you quotes free of charge with a real real time print out showing you rate comparison data. There happens to be just one such global company that offers this nice informative feature and they have 25,000 locations in 175 different countries. That represents the sort of accomplishment in holiday cars you will want to work with where ever you go.

Meet all of your holiday cars desires with a vehicle hire from italycarrentals.net. Worldwide service with over 25,000 locations and 550 automobile rental companies assures you of the lowest possible rates. Car hire Italy services for airports and train stations offering a large selection of cars, from minibus hire to flashy sports automobiles.

Source: http://travelandlesiure.therefinedgeek.com.au/index.php/2011/10/holiday-cars-which-will-prove-lowest-prices/

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Cell-specific mechanism-based gene therapy approach to treat retinitis pigmentosa

Cell-specific mechanism-based gene therapy approach to treat retinitis pigmentosa

Friday, September 30, 2011

In a paper published in the October 2011 issue of Experimental Biology and Medicine, a team of researchers at Columbia University Medical Center led by Stephen Tsang, MD, Ph.D have achieved temporary functional preservation of photoreceptors in a mouse model for retinitis pigmentosa (RP) using novel bipartite gene therapy.

RP is a heterogeneous disorder characterized by progressive degeneration of rod photoreceptors (which mediate night vision) causing night blindness and eventually total blindness. About 36,000 cases of simplex and familial RP worldwide are caused by mutant phosphodiesterase (PDE6). Says Dr. Tsang,

"Victor McKusick's Mendelian Inheritance in Man catalog has approximately 4,000 genetic disease entries, but only 4 of these are already curable by gene-therapy approaches. This bipartite vector, which allows cell-specific delivery of both the normal gene and shRNA to knockdown other genes in the pathway, represents a strategy that may help cure many more retinal degenerations. Degeneration of rod photoreceptors also affects approximately 9 million Americans with age-related macular degeneration. Strategies to save photoreceptors in mouse models of RP may be applicable to that disease as well."

In spite of this high prevalence, the interplay between defective PDE metabolism and RP pathogenesis remains poorly understood. In several mouse models for RP, defects in the PDE6B enzyme result in increased levels of the signaling molecules cGMP (mediated by GUCY2E cyclase) and Ca2+ (mediated by the CNGA1 channel).

Several aspects of the EBM report are innovative. It not only tackles the lack of functional PDE6? (by augmenting function with conventional gene replacement), but simultaneously counteracts the central biochemical impact of that lost function by decreasing abnormally accumulated cGMP and Ca2+. Furthermore, they used a tissue-specific promoter to achieve cell-specific expression of the transduced genes, which is unusual for shRNA delivery.

The researchers at Columbia developed three different lentiviral vectors, each of them designed to deliver wild-type Pde6b cDNA and one of two shRNAs. One vector delivered the cDNA and GUCY2E shRNA to reduce cGMP levels; another vector delivered the wild-type cDNA and CNGA1 shRNA to reduce Ca2+ levels; the third delivered the cDNA and the Gucy2e shRNA with a tissue-specific promoter. The bipartite approach was conceived as a way to improve therapeutic efficacy over that of a single-therapy approach, which was tested in an earlier project from Dr. Tsang's lab. While the current project did not show improvement over their previous work, the researchers are optimistic that bipartite delivery may represent an important resource in future explorations of gene therapy in the eye and other tissues types.

Typical existing shRNA vector systems use the RNA polymerase III promoter, which is expressed in essentially all cell types, to drive expression of the transduced gene. However, expression of shRNA targeting GUCY2E in cone photoreceptors, which mediates color vision, would have unwanted and deleterious effects on vision. To achieve rod-specific expression of the shRNA, the researchers in this work embedded Gucy2e shRNA into the Pol II transcription unit of pre-miR34, which is expressed solely in rods. Similar methods can be used to target different tissues, so this method may have wide applicability.

The testing of shRNA therapeutic approaches in Pde6bH620Q mice should facilitate pre-clinical therapeutic evaluation of retinitis pigmentosa. Lessons learned from the proposed studies will eventually be translated into strategies for treatment trials in larger animal models of PDE6? deficiency, such as Irish Setter dogs, before seeing application in human therapeutics.

Dr. Steve Goodman, Editor-in-Chief of Experimental Biology and Medicine said, "Researchers at Columbia University Medical Center led by Stephen Tsang, MD, Ph.D have used a unique gene therapy approach to preserve photoreceptors and prolong functional vision in a mouse model of retinitis pigmentosa (RP). There work offers the promise of a future gene therapy cure for RP".

###

Society for Experimental Biology and Medicine: http://www.sebm.org/

Thanks to Society for Experimental Biology and Medicine for this article.

This press release was posted to serve as a topic for discussion. Please comment below. We try our best to only post press releases that are associated with peer reviewed scientific literature. Critical discussions of the research are appreciated. If you need help finding a link to the original article, please contact us on twitter or via e-mail.

This press release has been viewed 75 time(s).

Source: http://www.labspaces.net/113900/Cell_specific_mechanism_based_gene_therapy_approach_to_treat_retinitis_pigmentosa

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RIM BlackBerry Bold 9930 (Sprint)

Sprint's version of the new BlackBerry Bold 9930 offers a few key differences next to the Verizon version, the most compelling of which is less expensive monthly data plans. It's still not a shoo-in for a recommendation, though. The Bold 9930 is a beautiful, fast cell phone?in search of a contemporary operating system. It's a slimmer, more responsive BlackBerry than before, but otherwise it's the same BlackBerry we've all known for years. That's fine for businesses which need mission-critical messaging, but for consumers, it's not enough to keep up with the latest Android and iOS devices with their thriving third-party app communities and more advanced multimedia features.

Design and Call Quality
The Bold 9930 measures 4.5 by 2.6 by 0.4 inches (HWD) and weighs 4.6 ounces. It's a classy-looking device, with its sharp aluminum accident band and thin, extra-wide QWERTY keyboard. Typing on it feels sublime; this is the best keyboard in the business. The 2.8-inch capacitive touch screen sports 640-by-480-pixel resolution, which is considerably sharper than the 360-by-480-pixel screens of earlier Bolds.

The Bold 9930 is a true world phone, with support for dual-band EV-DO Rev A (850/1900 MHz), quad-band EDGE (850/900/1800/1900 MHz), and dual-band HSDPA (850/1900 MHz). It also supports 2.4GHz 802.11b/g/n and 5GHz 802.11 a/n Wi-Fi networks. Sprint also unlocks the SIM card slot, unlike Verizon, so you can pop in something cheaper locally overseas if you don't mind losing your phone number temporarily. There's no mobile hotspot mode available, though, which puts it behind Sprint's numerous Android phones.?

In back to back comparisons with the Bold 9930 on Verizon, the Bold 9930 on Sprint sounded basically the same, despite the two different networks. Callers sounded crisp and bright, and there was plenty of volume available. I still heard a slight wash of static around individual syllables. Callers sounded I sounded okay, but not as good as I do through other Sprint phones. Reception was average; sometimes the phone dropped to 1xRTT mode, which is disappointing considering that earlier Sprint BlackBerrys from three years ago like the Pearl 8130 always stayed on EV-DO in my home.

Callers sounded clear through an Aliph Jawbone Era Bluetooth headset?($129, 4 stars). The Nuance-powered voice dialing worked perfectly over Bluetooth. The speakerphone had plenty of volume, but sounded a bit more distorted with than earlier Bolds. Battery life was considerably shorter than the Verizon version for some reason, at 5 hours and 37 minutes of talk time.?

User Interface, Apps, and BlackBerry App World
Most of the same things that make the Verizon Bold 9930 successful are present here. The 1.2GHz Qualcomm Snapdragon makes BlackBerry OS 7 fly. The WebKit browser is a godsend compared with earlier RIM devices, and works about as well as an Android or iPhone browser, only with a smaller screen and without Flash. The Bold 9930 continues to excel at messaging, with its built-in push email support, BlackBerry Messenger app, and threaded texting. You still can't sync with Microsoft Exchange without a BlackBerry Enterprise Server installed at your company, though.

Sprint adds its own flavor to the built-in software. The media folder collects most of Sprint's usual bloatware in one place, including Sprint TV, Sprint Music Plus, NASCAR Sprint Cup Mobile, and the GPS Navigation app, which offers solid, voice-enabled turn-by-turn directions for free with the appropriate unlimited data plans.

Unfortunately, the Bold 9930 on Sprint also shares the same downsides as the Verizon version. BlackBerry App World is a total embarrassment, a sluggish, ungainly app store that makes browsing, buying, and downloading apps unnecessarily difficult. BlackBerry OS 7, even with its various minor updates, still doesn't allow for the kinds of powerful apps that Android and iOS devices do. It's also tough to navigate the various complex icon and settings menus, unless you're a BlackBerry veteran, in which case it will feel exactly like what you're used to.

Multimedia, Camera, and Conclusions
The Bold 9930 is a great music player, but just a so-so video player and camera. First, the music part: there's a standard-size 3.5mm headphone jack, 8GB of internal memory, and a microSD card slot that accepts 32GB cards. The microSD card slot is buried behind the battery, which is one frustration in an otherwise smooth media experience. Music tracks sound crisp and clear through Samsung Modus HM6450 Bluetooth headphones?($99, 4 stars), and the jukebox-like album cover display is fun to scroll back and forth.

It's the camera and video that can use some improvement. The camcorder portion is fine; it's finally 720p HD-capable, records smooth 1280-by-720-pixel files at an even 30 frames per second, and sports a useful image stabilization feature that helps with hand jitters. The standalone camera itself isn't as good. While it's a decent 5-megapixel sensor and has an LED flash, it lacks auto-focus, and it doesn't take particularly sharp or vibrant photos. You can watch videos on the Bold 9930, and they play back relatively smoothly, but the 2.8-inch, 4:3 aspect ratio screen means widescreen movie files look exceptionally small.?

I like Sprint's version of this phone slightly better than Verizon's and T-Mobile's, thanks to the Sprint Bold 9930's lower up-front price, and Sprint's lower-cost, unlimited data plans. As a result, if Sprint's coverage area works better for you or your employees, this Bold 9930 is the way to go. That said, it's an old smartphone in sleek new clothing. If you can live without a hardware keyboard, the much-more contemporary Motorola Photon 4G ($199.99, 4.5 stars) is an awesome, Android-powered alternative, with its high-res 960-by-540-pixel screen, dual-core CPU, and 4G WiMAX capability, plus access to over 200,000 apps in Android Market. The Photon 4G is another world phone as well, with both CDMA and HSPA 14.4 support and an unlocked SIM card slot. If a hardware keyboard is a must, the Samsung Epic 4G ($149.99, 4 stars) remains Sprint's best keyboarded smartphone; it's slower than the Photon, but it still hits WiMAX networks, and still has higher screen resolution and access to all those Android apps.

Benchmarks
Continuous talk time: 5 hours 37 minutes

More Cell Phone Reviews:??? RIM BlackBerry Torch 9850 (Verizon Wireless)??? Motorola Droid Bionic (Verizon Wireless)??? RIM BlackBerry Bold 9900 (T-Mobile)??? RIM BlackBerry Bold 9930 (Sprint)??? RIM BlackBerry Style 9670 (Boost Mobile)?? more

Source: http://feedproxy.google.com/~r/ziffdavis/pcmag/~3/d8yd-RROWqw/0,2817,2392581,00.asp

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Obama to speak at Joint Chiefs change of command (AP)

WASHINGTON ? President Barack Obama will speak Friday morning at the swearing-in of the new chairman of the Joint Chiefs of Staff.

Adm. Mike Mullen is retiring after serving four years as chairman and more than 40 years in uniform. He will be handing the reins to Army Gen. Martin Dempsey, who will become the 18th chairman.

Vice President Joe Biden will also attend the ceremony at Fort Myer in suburban Washington.

In the afternoon, the president will be interviewed live by talk-show host Michael Smerconish (smur-KAHN'-ihsh). It's Obama's third interview with Smerconish since taking office.

In the evening, the president will deliver remarks at a campaign event at a private residence in Washington.

Source: http://us.rd.yahoo.com/dailynews/rss/obama/*http%3A//news.yahoo.com/s/ap/20110930/ap_on_go_pr_wh/us_obama_preview

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Nargis bonds with Ranbir?s mom

Ranbir Kapoor recently had quite a star studded birthday bash. Many B?town Celebs with whom the youth icon has worked till now were invited at the party. The long list of guests also included his ex flames Deepika Padukone, Priyanka Chopra and Nargis Fakri. However, what caught everyone?s attention was Ranbir Kapoor?s mother Neetu Kapoor?s [...]

Source: http://feedproxy.google.com/~r/newslatest/~3/92txsgtINFs/2053.html

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Ashton Kutcher?s Jump Off Is Looking For A Big Payday

Blonde Sara Leal, who reportedly slept with Ashton Kutcher last weekend, is working overtime to cash in on the scandal. Sources say she?s working with an ex-lover-turned club promoter to sell her story. She?s also in cahoots with a paparazzo who plans to sell staged new ?street? pictures of Leal. ?She gets a cut of [...]

Source: http://www.celebritymound.com/ashton-kutchers-jump-off-is-looking-for-a-big-payday/?utm_source=rss&utm_medium=rss&utm_campaign=ashton-kutchers-jump-off-is-looking-for-a-big-payday

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Investing in Africa's Energy Sector: Challenges & Opportunities ...

Featuring:

Joseph Brandt
President and CEO, ContourGlobal

Robert A. Mosbacher, Jr.
Former President and CEO, Overseas Private Investment Corporation (OPIC)
Chairman, Mosbacher Energy Company

Paul Hanrahan (invited)
President and CEO, AES Corporation

Moderated by:

David Pumphrey
Deputy Director and Senior Fellow

CSIS Energy and National Security Program

Introductory Remarks by:

Henrietta H. Fore
Chairman and CEO, Holsman International?

Richard Downie
Deputy Director, CSIS Africa Program

?

Thursday, October 6, 2011

12:00pm-1:30pm

B1 Conference Center

CSIS 1800 K St. NW, Washington, DC 20006
?

Much of the African continent still lacks access to power and electricity. Immense challenges exist to changing this reality: regulatory structures are complicated and difficult to navigate; large investments are needed; and long-term financing is often difficult to secure. On this panel we will hear from a range of experts on the various challenges and opportunities to investing in Africa's power sector. Leaders in the industry will share their experiences working in Africa's underserved energy market, and the discussion will build upon the broader policy work focusing on the stimulation of economic growth in Africa.

?

Lunch will be served.?

?

In order to ensure we can reserve your seat and meal,?

Source: http://csis.org/event/investing-africas-energy-sector-challenges-opportunities

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Garmin 2350Lmt GPS - Why This Really Is Such A Well-known And ...

The Nuvi 2350LMT is an entry degree gadget that provides the client an amazing array of route planning features inside a single, modest, very portable, slender device. The Garmin 2350LMT has touch screen functions, a wide LCD show screen with TFT technologies, QVGA color technologies, as well as the screen has antiglare properties so it might be used in vivid sunlight. The Garmin 2350LMT also has a entire host of characteristics that make travel organizing pleasant and effortless.
1st, when utilizing the capabilities from the Garmin 2350LMT the user will uncover that all street names, upcoming turns, and needed distance coverage is announced vocally. The minute one particular turns the device on they may be provided to simple to make use of icons which let you view maps or to input route addresses. You?ll be able to search for distinct addresses, indicate the planned destination, as well as the Garmin Nuvi 2350LMT does each of the rest from the function by presenting you with three dimensional maps of the planned route and complete, clear, simple to hear, vocalized instructions. This device is sold with maps of Mexico, the United states, and Canada and maps could be extra to it inside the long term if one particular desires.
The Garmin Nuvi 2350LMT allows you to navigate your strategy to immediate points of interest which are loaded onto the device when you purchase it. This means you?ll be able to find automatic tellers, gas stations, entertainment areas, hotels and accommodations, local stores, and restaurants all with the single touch in the Garmin 2350LMT?s show. What is a lot more, it is possible to update the maps on the Garmin 2350LMT as much as as a lot of as four times annually so you might be usually notified in the most current routes offered to any destination.
The Garmin 2350LMT lets you choose what routes you would like to take to every destination. You?ll be able to use ecoRoute? characteristics should you be looking for to save funds on fuel fees, or you?ll be able to strategy a route according to off road options. In the event you don?t wish to spend tolls or take highways you are able to program routes based upon your preferences. If you?re seeking the most immediate route to get to a place or you need to know the shortest distance, the Garmin 2350LMT can help you with that too. Meanwhile, pedestrian users that strategy to utilize the Garmin Nuvi 2350LMT even though on foot can avail themselves of items like cityXplorer?: this function will point you in the proper direction if you are seeking out handy modes of transit like buses, subways, and trams.
The Garmin Nuvi 2350LMT can hold up to 100 routes, and the device is even capable of sorting and managing numerous destinations. No matter whether you happen to be arranging a single route or you find that you simply all of a sudden need to reroute your original travel plans, the Garmin 2350LMT has every one of the tools you need to produce route planning exceptionally simple. Lastly, the value you are going to pay for the Garmin Nuvi 2350LMT is much more than really worth the initialinvestment: you get an impressive travel preparing tool at an extraordinary price.
What do others must say about their experiences using the Garmin Nuvi 2350LMT?

Check Out Garmin 2350Lmt Review to Get Special Offer For Limited Stock!

Source: http://d-london.com/communications/garmin-2350lmt-gps-why-this-really-is-such-a-well-known-and-quality-satellite-navigation-system/

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