FDA yanks Avastin as breast cancer drug - Healthy Living : The ...

FDA yanks Avastin as breast cancer drug

November 18th, 2011, 10:33 am ? ? posted by Courtney Perkes

The Food and Drug Administration on Friday announced that the blockbuster drug Avastin is no longer approved as a treatment for breast cancer because of potentially life-threatening side effects and a lack of benefit to patients.

The FDA said risks include:? severe high blood pressure; bleeding and hemorrhaging; heart attack or heart failure; and the development of perforations in the nose, stomach, and intestines.

The FDA said the drug, made by Genentech, was approved for metastatic breast cancer in February 2008 through an accelerated approval process designed to give patients access to promising drugs while clinical trials are conducted.

Avastin will remain on the market as treatment for other kinds of cancer, including colon cancer.

Read more about the FDA?s decision here.

Text OCRHEALTH to 56654 to get free health news alerts.

Source: http://healthyliving.ocregister.com/2011/11/18/fda-yanks-avastin-as-breast-cancer-drug/42913/

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What Is the LRAD Sound Cannon? [Video]

The Occupy movement has become of the longest large-scale protests in US history, and all that protesting had pitted the activists against police departments and their crowd-control weapons. One of the more controversial of those is the LRAD Sound Cannon. So what's the harm in a little noise? Well, a lot, actually. More »


Source: http://feeds.gawker.com/~r/gizmodo/full/~3/hvNXIjq0WrI/what-is-the-lrad-sound-cannon

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Spanish bond auction sees interest rate near 7 pct (AP)

MADRID ? Spain paid an interest rate of nearly 7 percent to raise euro3.56 billion ($4.8 billion) in an auction of 10-year bonds Thursday, the highest rate since 1997 and a level seen as unsustainable over the long term.

The finance minister insisted, however, that a bailout was out of the question and said Spain's overall debt load ? about 70 percent of gross domestic product ? is manageable.

"The sustainability of our debt is beyond any doubt," Elena Salgado told Cadena Ser radio.

She said the 2011 budget had allotted euro27 billion for debt interest payments and "even with all this tension we are going to spend 3 billion less."

Salgado also said at least 12 of the 17 countries that use the euro are seeing their borrowing costs rise, so Spain is not a special case.

"We are seeing systematic attacks on our sovereign debt" the minister said. "Today it is Spain, yesterday it was Italy, the day before that it could have been Belgium, and tomorrow it could be any other country, even the ones considered central to the euro, such as Austria or France."

Thursday's rate of 6.97 percent compared with 5.43 percent in the last such auction Oct. 20.

Demand was relatively weak. The amount of debt sold came in under the euro4 billion maximum target set by the Treasury and the bid to cover ratio was 1.54, compared with 1.76 last time.

After the auction, yields on Spanish 10-year bonds shot up. In early afternoon they stood at 6.79 percent on the secondary market. That was 4.93 percentage points above the yield of the equivalent benchmark German bund.

Spain's chapter of the European debt crisis has engulfed the campaign for Sunday's general elections.

Opposition conservatives are expected to score a landslide win over the ruling Socialists, saddled with an economy that has 21.5 percent unemployment, posted zero growth in the third quarter and is not expected to improve much next year.

Spain is struggling to recover significant economic growth after enduring nearly two years of recession prompted in part by the collapse of a real estate bubble. It is the periodic focus of fears it will be the next eurozone country to require a bailout, after Greece, Ireland and Portugal.

___

Ciaran Giles and Jorge Sainz contributed to this report.

Source: http://us.rd.yahoo.com/dailynews/rss/eurobiz/*http%3A//news.yahoo.com/s/ap/20111117/ap_on_bi_ge/eu_spain_financial_crisis

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DWTS Week 9 Results: Did Hope Solo Finally Get The Boot?

…And then there were three. Of the remaining four contestants – Ricki Lake, J.R. Martinez, Rob Kardashian and Hope Solo, who will not be returning next week to take part in the finals? Was Monday’s last place contestant, Hope Solo, voted off? Or did the injured veteran and actor J.R. Martinez get sent packing? Find out below! An encore performance of Rob Kardashian and Cheryl Burke’s sassy samba was requested by the judges, and yes, what a joy it was to watch again with all that booty shakin’ on Rob’s part. Just amazing how far he has come, eh? It’s time for some results. He is rewarded for a job well done last night, as Rob and Cheryl are headed to the finals! Ooooh, Cobra Starship featuring Sabi are on stage to perform “You Make Me Feel”. Oh, there’s Kym Johnson and Tristan MacManus along with Sharna and Sonny accompanying them. I miss Tristan… Loved seeing Carson Kressly again, who introduced us to the wardrobe department. Or as Tom put it, ‘We sent Carson Kressley INTO the closet’. Ha ha ha ha. You can imagine how in the element he is, telling Rob that adding ruffles to his sleeves will [...]

Source: http://feedproxy.google.com/~r/RightCelebrity/~3/lhUJ7cjEEHs/

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Supervolcanoes: Not a threat for 2012

ScienceDaily (Nov. 15, 2011) ? The geological record holds clues that throughout Earth's 4.5-billion-year lifetime massive supervolcanoes, far larger than Mount St. Helens or Mount Pinatubo, have erupted. However, despite the claims of those who fear 2012, there's no evidence that such a supereruption is imminent.

What exactly is a "supervolcano" or a "supereruption?" Both terms are fairly new and favored by the media more than scientists, but geologists have begun to use them in recent years to refer to explosive volcanic eruptions that eject about ten thousand times the quantity of magma and ash that Mount St. Helens, one of the most explosive eruptions in recent years, expelled.

It's hard to comprehend an eruption of that scope, but Earth's surface has preserved distinctive clues of many massive supereruptions. Expansive layers of ash blanket large portions of many continents. And huge hollowed-out calderas -- craters that can be as big as 60 miles (100 km) across left when a volcano collapses after emptying its entire magma chamber at once -- serve as visceral reminders of past supereruptions in Indonesia, New Zealand, the United States, and Chile.

The eruption of these prehistoric supervolcanoes has affected massive areas. The magma flow of Mount Toba in Sumutra, which erupted some 74,000 years ago in what was likely the largest eruption that has ever occurred, released a staggering 700 cubic miles (2,800 cubic km) of magma and left a thick layer of ash over all of South Asia. For comparison, the quantity of magma erupted from Indonesia's Mount Krakatau in 1883, one of the largest eruptions in recorded history, was about 3 cubic miles (12 cubic km).

Volcanologists continue to seek answers to many unanswered questions about supervolcanoes. For example, what triggers their eruptions, and why do they fail to erupt until their magma chambers achieve such enormous proportions? How does the composition compare to more familiar eruptions? And how can we predict when the next supervolcano will erupt?

But there's one thing that all experts agree on: supereruptions, though they occur, are exceedingly rare and the odds that one will occur in the lifetime of anybody reading this article are vanishingly small.

The most recent supereruption occurred in New Zealand about 26,000 years ago. The next most recent: the cataclysmic eruption of Mount Toba happened about 50,000 years earlier. In all, geologists have identified the remnant of about 50 supereruptions, though teams are in the process of evaluating a number of other possibilities.

That may sound like a large number. However, when one group of scientists used the count of all the known supervolcanoes to calculate the approximate frequency of eruptions, they found that only 1.4 supereruptions occur every one million years.

That's not to say that a supervolcano will occur every million years at regular intervals. Many millions of years could pass without a supereruption or many supervolcanoes could erupt in just a short period. The geological record does suggest supervolcanoes occur in clusters, but the clusters are not regular enough to serve as the basis for predictions of future eruptions.

Scientists have no way of predicting with perfect accuracy whether a supervolcano will occur in a given century, decade, or year -- and that includes 2012. But they do keep close tabs on volcanically active areas around the world, and so far there's absolutely no sign of a supereruption looming anytime soon.

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The above story is reprinted from materials provided by NASA/Goddard Space Flight Center.

Note: Materials may be edited for content and length. For further information, please contact the source cited above.


Note: If no author is given, the source is cited instead.

Disclaimer: Views expressed in this article do not necessarily reflect those of ScienceDaily or its staff.

Source: http://www.sciencedaily.com/releases/2011/11/111115180313.htm

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Windows 8 Is Coming To Phones, Says Steve ... - Business Insider

Steve Ballmer seemed to say that Microsoft is planning to put Windows 8 on phones.

This morning at the company's shareholders' meeting, a shareholder asked if we were in the post-PC era.

He started off his answer by insisting that we will ALWAYS be in the Windows era, then said "We've got broad Windows initiatives, driving Windows down to the phone with Windows 8."*

However, Microsoft now says he was talking generally about driving Windows down to the phone, and then went on to talk about other Windows 8 form factors, like tablets.

Microsoft execs have said that they plan to unify the mobile and desktop platforms in coming years.

However, this probably does NOT mean that the next version of Windows Phone will look and run exactly the same as the Windows 8 desktop ? phones and PCs are different animals in Microsoft's view, and therefore require different interfaces.

But it could mean that the next version of Windows Phone will use the same NT kernel that's at the heart of the Windows desktop and Windows Server operating systems, instead of the CE kernel that has been the basis of all Microsoft mobile platforms. This has been the subject of some intense speculation among Microsoft watchers recently, and Ballmer just seemed to confirm it.

That could make it easier to port apps between multiple Microsoft devices, including PCs, tablets, and phones. There are other factors as well ? PCs will use Intel-type x86 and x64 chips for the foreseeable future, while phones will probably stay on ARM-based processors, with tablets spanning both worlds.

But in general, it makes sense for Microsoft to maintain and support only one kernel for all platforms.

*Update: Microsoft says that Ballmer didn't say that Windows 8 is coming to Windows Phone. Here's the official transcript:

We've got broad Windows initiatives driving Windows down to the phone. With Windows 8, you'll see incredible new form factors powered by Windows from tablets, small, large, pens, smaller, bigger, room-sized displays.

Todd Bishop at Geekwire heard it this way as well.

We heard:

We've got broad Windows initiatives, driving Windows down to the phone with Windows 8. You'll see incredible new form factors powered by Windows, from tablets, small, large, pens, smaller, bigger, room-sized displays.

But pause or no pause, that's not what he meant.

Check it out for yourself:

Source: http://www.businessinsider.com/windows-8-is-coming-to-phones-says-steve-ballmer-2011-11

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When Did Childbirth Become Everyone's Business? - NYTimes.com

I was tricked into a natural childbirth. As the midwife hauled me from birthing tub to hallway walk to music-filled, softly lit delivery room, I kept saying, no, thanks. No more tub. No music. Narcotics. Now. Actually, birth being what it is for me, I screamed it. But my midwife was determined that I would become the natural childbirth success story I?d never particularly wanted to be.

In retrospect, I don?t resent her disregard for what I thought I wanted (even though I swear she said I could have drugs). I?d chosen to give birth with her, in the hospital, because I trusted her. She was also with me, less than two years later, for my emergency Caesarean section. But my only goals for giving birth were that it be easy (never achieved) and successful (nailed three times). Other people, as evidenced by my midwife, may care a great deal about how women give birth. Some care that we do it their way, whether that?s a nice, convenient, scheduled C-section, a beautiful, empowering home birth or something in between. Others just want women to be able to give birth according to our own wishes and choices, an idea that sounds perfectly reasonable until you?re in a position to realize that the baby clearly did not read the birth plan. Somewhere after births left the home in the 1920s (back when as many as one in eight women died in childbirth) and before the Caesarean rate in some private clinics in Brazil reached up towards 90 percent, how women give birth became an ?issue? instead of a private matter.

Into all of this, in 2008, came ?The Business of Being Born,? a documentary produced by Ricki Lake and directed by Abby Epstein. Ms. Lake and Ms. Epstein set out to pull the curtain back on the ways giving birth may no longer be controlled by the mother or by the baby, but by outside forces, some with good intentions and some without. This year, they?ve followed it up with the release of ?More Business of Being Born,? a four-DVD sequel filled with more births, birth stories and interviews with pioneers in the holistic childbirth movement.

Ms. Lake and Ms. Epstein intended to empower and inform women and to promote alternatives to the hospital default choice. While they?re clearly fans of home births, you can see their movies and be moved to push for changes in hospitals and birthing centers rather than a total return to the days of yore. Or you can see them and become, as the? Entertainment Weekly film critic Owen Gleiberman did, a complete, passionate and misguided (or at least misinformed) convert. Mr. Gleiberman, whose wife gave birth at home last year, admits his bias, but that doesn?t stop him from filling his approving review of the movie itself with the zealous but dubious statements of a proselyte.

His review raises the specter of Brazil?s ?sci-fi nightmare? 93 percent C-section rate happening here (that rate is exaggerated; countrywide it?s closer to 37 percent ? still startling, but far less dramatic). Instead, hospitals across the country are actually banning elective early deliveries (in itself arguably an intrusion over a woman?s right to choose her birth experience). He insists that ?in a hospital, the baby is taken away from you? right after birth, which may be true in some hospitals, but certainly not all. He cites the statistic, favored by home birth advocates, that home birth is ?safer? than hospital birth. He declares, without attribution, that the ?numbers don?t lie.? I?m not opposed to home births. But the most cursory research reveals credible studies both supporting and questioning home birth safety.

Shouldn?t I let one new dad neophyte off the hook for his enthusiasm? I would, except that his public zeal impacts others. It?s one thing to support an informed decision about home or hospital birth, and another to promote an antagonistic relationship between the two, which serves no one. See the ?The Business of Being Born.? Watch the sequel, if you?re up to four more DVDs worth of birthing. Talk to, as the trope goes, your health care provider. But the advice from your local film critic? I?d skip that.

Source: http://parenting.blogs.nytimes.com/2011/11/16/when-did-childbirth-become-everyones-business/

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'Breaking Dawn' Birth 'Emotional' For Stephenie Meyer

'Twilight' author also raves to MTV News about wedding and honeymoon — and reveals whether she'll write more about Bella and Edward.
By Kara Warner, with reporting by Josh Horowitz


Stephenie Meyer
Photo: Jason Merritt/ Getty Images

Of all the lovely and talented stars we feature in our exhaustive efforts to cover anything and everything in the world of "Twilight," it's a rare treat to talk to the woman responsible for it all: author-turned-producer Stephenie Meyer.

MTV News was lucky enough to catch up with the lady, the myth, the legend during our "Breaking Dawn - Part 1" premiere live stream Monday night (November 14), when we covered hot topics such as the wedding and honeymoon, the birth scene and whether Meyer will ever write another "Twilight"-themed story or book.

"With the wedding, I worked pretty closely with [screenwriter] Melissa [Rosenberg]," Meyer said. "We talked about it, how it needed to be like a really beautiful traditional ceremony, nothing outlandish, just simple and old-fashioned and romantic, and then [director] Bill [Condon] brought in the vision of what it should look like, and the production designer just made such a gorgeous midsummer night's dream for us. And then the final element was Kristen [Stewart] in the wedding dress. She was so gorgeous, she was unbelievable."

Will They Be Able To Pull Off the Birth Scene? Predict It on Facebook

Fun fact about the wedding scene: Meyer has a cameo, which she assured us was not her idea.

"Bill really wanted those of us who'd been there from the beginning [in the scene]," she said. "It was nice to be at Bella's wedding; that was great. Being on camera — not so much."

Moving right along to arguably the film's most-anticipated scene: the honeymoon, which Meyer said she wanted all along to be romantic above everything else.

"I think it's romantic, and it does give you more than the book does. I know some of the sites call it, instead of 'fade to black,' 'fade to sad.' they'd love to see more. I think this gives them that," she said. "It gives them a romantic peek into the honeymoon. We don't want to see too much."

Another scene in which the filmmakers incorporated a less-is-more approach was during the very intense birth scene, which Meyer said was so emotional that people shed a bunch of tears during filming.

"It was so emotional. It wasn't like a horror movie or anything. It has those elements, but it really brought out that feeling of losing the person that means the most to you. We were getting teary on set, which doesn't happen very much after a long day of shooting," she said. "That moment really was strong."

And finally, the question on all "Twilight" fans' minds all the time: After the final movie opens and things are all said and done, will Meyer return to her characters and continue the story?

"I don't know," she said. "Every now and then I tinker around with old manuscripts, because I can't leave them alone even though it's too late and they're printed. There are little things. I've been recently doing comedies and stuff; it's a nice change. Maybe it will cleanse the palate and I'll get back to it."

So once the palate is cleansed, might she consider publishing the much-discussed, fan-pined-for book from Edward's perspective, "Midnight Sun"? "Maybe. I get that [question] a lot," Meyer said. "My mother [asks] every day. She would love for me to do that. I know a lot of people will love that. I have to get to a place where I can write it."

Stick with MTV News as we roll out even more from our "Breaking Dawn" premiere live stream!

Check out everything we've got on "The Twilight Saga: Breaking Dawn - Part 1."

For young Hollywood news, fashion and "Twilight" updates around the clock, visit HollywoodCrush.MTV.com.

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Source: http://www.mtv.com/news/articles/1674382/breaking-dawn-stephenie-meyer.jhtml

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Supercommittee starts looking for plan B (Politico)

Lawmakers plodded through another day of wrenching negotiations on the deficit-cutting supercommittee, ratcheting up the partisan rhetoric and increasing their demands ahead of its mandated deadline, just a week away.

As Democrats continued to demand more revenue increases and Republicans called for deeper cuts to health care programs, there was increased chatter about the next steps to break the stalemate and avoid the full mandated budget cuts if no agreement is reached before Thanksgiving. One plan would have the supercommittee vote on competing Republican and Democratic proposals, aimed at forcing the other side?s hand.

Continue Reading

Republicans, meanwhile, have begun pondering potential fallback plans, including moving legislation that would most likely cut less than $1.2 trillion but softens the blow of the mandated cuts. There?s even talk of coupling a deficit-reduction package with must-pass measures like unemployment insurance to sweeten the deal for Democrats and President Barack Obama.

Democratic negotiators said Wednesday they were open to some parts of the leading GOP proposal floated by Pennsylvania Sen. Pat Toomey. And aides said Sen. Patty Murray (D-Wash.) quietly proposed a counteroffer last Friday to meet the GOP dollar-for-dollar on $876 billion in spending reductions and $401 billion in revenue-raisers, down from Democrats? initial call of $1 trillion in higher revenues.

Still, they were demanding several significant changes, including for the GOP to drop proposed benefit cuts to Social Security and Medicare and calls to permanently extend the Bush tax cuts. Republicans immediately dismissed the plan as a ?step backward,? attacking Democrats for seeking $300 billion in spending on jobs measures and for opposing their plans to make the Bush tax cuts permanent.

In sum, all the maneuvering seemed to paint a picture of confusion, panic and blame-passing as Congress, with approval ratings in the gutter, attempts to patch up yet another fiscal mess.

On a day when the national debt surpassed $15 trillion, the six Democrats and six Republicans on the supercommittee met separately in tense closed-door meetings and strategized with congressional leaders. In phone calls and personal meetings, Republicans discussed proposals old and new a half-dozen times ? and each side struggled to coalesce around plans that could pass bipartisan muster, or be used to maximize political cover.

?We?re trying to explore every avenue that?s got some potential,? said Arizona Sen. Jon Kyl, the Republican whip and a chief negotiator.

It became a certainty on Wednesday that any final deal would need to be struck at the end of the weekend, as the Congressional Budget Office needs to analyze any last-ditch proposal on Monday.

?I was here all last weekend ? I plan to be here all this weekend,? said Sen. Rob Portman (R-Ohio), another member of the panel.

The same sticking points that have prevented Congress from cutting a major budget deal are once again threatening the success of a committee granted sweeping authority to get a handle on the country?s burgeoning deficit. Democrats are not satisfied with the $250 billion in higher tax revenues proposed by the GOP, calling it paltry because it is coupled with the extension of the Bush-era tax cuts.

?I am still hopeful that the Republicans will see their way to bringing to us a real revenue package, and that?s what all of us are looking for in terms of fair and balanced,? said Murray, co-chair of the panel. ?We can?t let wealthy Americans continue to be given a shot out of this and everybody else has to bear the burden.?

Republicans counter that Democrats must cut deeper into health care programs than they have already proposed to Medicare and Medicaid. And until they do that, GOP negotiators said they would not put forward a new plan. Asked if Republicans could offer more than $250 billion in new revenue, Rep. Jeb Hensarling (R-Texas), the other co-chair, said he was not ?rejecting any offer out of hand? ? signaling, for the first time, openness on increasing revenues.

Source: http://us.rd.yahoo.com/dailynews/rss/politics/*http%3A//us.rd.yahoo.com/dailynews/external/politico_rss/rss_politico_mostpop/http___www_politico_com_news_stories1111_68550_html/43627719/SIG=11m8hvkig/*http%3A//www.politico.com/news/stories/1111/68550.html

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